Sub-nanoliter metabolomics via mass spectrometry to characterize volume-limited samples

Yafeng Li; Marcos Bouza; Changsheng Wu; Hengyu Guo; Danning Huang; Gilad Doron; Johnna S. Temenoff; Arlene A. Stecenko; Zhong Lin Wang; Facundo M. Fernández

doi:10.1038/s41467-020-19444-y

Nature Communications (Nov 2020)

Sub-nanoliter metabolomics via mass spectrometry to characterize volume-limited samples

Yafeng Li,
Marcos Bouza,
Changsheng Wu,
Hengyu Guo,
Danning Huang,
Gilad Doron,
Johnna S. Temenoff,
Arlene A. Stecenko,
Zhong Lin Wang,
Facundo M. Fernández

Affiliations

Yafeng Li: School of Chemistry and Biochemistry, Georgia Institute of Technology
Marcos Bouza: School of Chemistry and Biochemistry, Georgia Institute of Technology
Changsheng Wu: School of Materials Science and Engineering, Georgia Institute of Technology
Hengyu Guo: School of Materials Science and Engineering, Georgia Institute of Technology
Danning Huang: School of Chemistry and Biochemistry, Georgia Institute of Technology
Gilad Doron: W.H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Johnna S. Temenoff: W.H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
Arlene A. Stecenko: Emory + Children’s Center for Cystic Fibrosis and Airways Disease Research and Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta
Zhong Lin Wang: School of Materials Science and Engineering, Georgia Institute of Technology
Facundo M. Fernández: School of Chemistry and Biochemistry, Georgia Institute of Technology

DOI: https://doi.org/10.1038/s41467-020-19444-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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The analysis of metabolites offers promises in biomarker discovery. Here the authors demonstrate the metabolomics analysis of sub-nanoliter samples using triboelectric nanogenerator inductive nanoelectrospray ionization, which they apply to exhaled breath condensate from cystic fibrosis patients and mesenchymal stromal cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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