BMC Neurology (Apr 2023)

Enlightening the association between TNF-α -308 G > A and migraine: a meta-analysis with meta-regression and trial sequential analysis

  • Amrit Sudershan,
  • Srishty Sudershan,
  • Mohd Younis,
  • Meenakshi Bhagat,
  • Agar Chander Pushap,
  • Hardeep Kumar,
  • Parvinder Kumar

DOI
https://doi.org/10.1186/s12883-023-03174-x
Journal volume & issue
Vol. 23, no. 1
pp. 1 – 14

Abstract

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Abstract Background Migraine is a complex neurological disorder that is characterized by a "lower threshold of neuronal hyperexcitability" with distinctive periodicity and complex vascular dysfunction. Genetic factors have impacted incredibly on the susceptibility of migraine and one such example is the TNF-α 308G > A. Aim Therefore, we aim to provide a glimpse of the association of the TNF-α 308G > A risk on the susceptibility of migraine. Method The pooled odds ratio with the associated 95% of confidence interval were calculated using different genetic models. Heterogeneity was accessed by using Cochran's Q Test and I2 statistics and Begg's and Egger's tests were used for finding the publication bias, tests were two-sided, and a p-value of A increases the risk of migraine only in the Asian population.

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