Frontiers in Nutrition (May 2023)
Derivation and validation of a nutrition-covered prognostic scoring system for extranodal NK/T-cell lymphoma
- Tiange Lu,
- Tiange Lu,
- Tiange Lu,
- Xue Shi,
- Xueling Ge,
- Xueling Ge,
- Xueling Ge,
- Xueling Ge,
- Ying Li,
- Yiqing Cai,
- Yiqing Cai,
- Yiqing Cai,
- Xiaomin Chen,
- Xiaomin Chen,
- Xiaomin Chen,
- Shunfeng Hu,
- Shunfeng Hu,
- Shunfeng Hu,
- Mei Ding,
- Mei Ding,
- Mei Ding,
- Mei Ding,
- Xiaosheng Fang,
- Xiaosheng Fang,
- Xiaosheng Fang,
- Xiaosheng Fang,
- Fang Liu,
- Xiangxiang Zhou,
- Xiangxiang Zhou,
- Xiangxiang Zhou,
- Xiangxiang Zhou,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang
Affiliations
- Tiange Lu
- Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Tiange Lu
- Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Tiange Lu
- School of Medicine, Shandong University, Jinan, Shandong, China
- Xue Shi
- Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
- Xueling Ge
- Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Xueling Ge
- Shandong Provincial Engineering Research Center of Lymphoma, Jinan, Shandong, China
- Xueling Ge
- Branch of National Clinical Research Center for Hematologic Diseases, Jinan, Shandong, China
- Xueling Ge
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Ying Li
- Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
- Yiqing Cai
- Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Yiqing Cai
- Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Yiqing Cai
- School of Medicine, Shandong University, Jinan, Shandong, China
- Xiaomin Chen
- Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Xiaomin Chen
- Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Xiaomin Chen
- School of Medicine, Shandong University, Jinan, Shandong, China
- Shunfeng Hu
- Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Shunfeng Hu
- Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Shunfeng Hu
- School of Medicine, Shandong University, Jinan, Shandong, China
- Mei Ding
- Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Mei Ding
- Shandong Provincial Engineering Research Center of Lymphoma, Jinan, Shandong, China
- Mei Ding
- Branch of National Clinical Research Center for Hematologic Diseases, Jinan, Shandong, China
- Mei Ding
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Xiaosheng Fang
- Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Xiaosheng Fang
- Shandong Provincial Engineering Research Center of Lymphoma, Jinan, Shandong, China
- Xiaosheng Fang
- Branch of National Clinical Research Center for Hematologic Diseases, Jinan, Shandong, China
- Xiaosheng Fang
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Fang Liu
- Department of Psychiatry, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
- Xiangxiang Zhou
- Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Xiangxiang Zhou
- Shandong Provincial Engineering Research Center of Lymphoma, Jinan, Shandong, China
- Xiangxiang Zhou
- Branch of National Clinical Research Center for Hematologic Diseases, Jinan, Shandong, China
- Xiangxiang Zhou
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Xin Wang
- Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Xin Wang
- Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Xin Wang
- School of Medicine, Shandong University, Jinan, Shandong, China
- Xin Wang
- Shandong Provincial Engineering Research Center of Lymphoma, Jinan, Shandong, China
- Xin Wang
- Branch of National Clinical Research Center for Hematologic Diseases, Jinan, Shandong, China
- Xin Wang
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- DOI
- https://doi.org/10.3389/fnut.2023.1080181
- Journal volume & issue
-
Vol. 10
Abstract
IntroductionPatients with aggressive lymphomas are at high risk of losing body resources, resulting in malnutrition, immunodeficiency and inferior outcomes. Nutritional status is closely associated with survival, but often neglected in the prognostic assessment. This study aimed to explore the significance of nutritional status in extranodal NK/T-cell lymphoma (ENKTL).MethodsUnivariate and multivariate Cox regression analyses were conducted to examine the significance of nutritional index on overall survival (OS) and progression-free survival (PFS). A nutrition-incorporated score system was constructed based on the multivariate results, and its calibration, discrimination and clinical utility were tested in the training and validation cohort.ResultsMultivariate analysis revealed controlling nutritional status (CONUT) score could independently predict OS (HR 10.247, P=0.001) and PFS (HR 5.587, P=0.001) in addition to prognostic index of natural killer lymphoma plus EBV (PINK-E). Herein, a reformative model, CONUT-PINK-E, was developed and further verified in external validation cohort. CONUT-PINK-E classified patients into three risk grades with significant survival differences (P < 0.001). Compared with the current models, CONUT-PINK-E presented superior discrimination, calibration and clinical benefit.DiscussionIn this study, we firstly verified that CONUT score was efficient to screen prognosis-related malnutrition in ENKTL. Moreover, we developed the first nutritional assessment-covered scoring system, CONUT-PINK-E, which might be a promising tool to provide references for clinical decision-making of ENKTL patients.
Keywords
