Heliyon (Apr 2023)
Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group
- Huisheng Ai,
- Nelson J. Chao,
- David A. Rizzieri,
- Xiaojun Huang,
- Thomas R. Spitzer,
- Jianxiang Wang,
- Mei Guo,
- Armand Keating,
- Elizabeth F. Krakow,
- Didier Blaise,
- Jun Ma,
- Depei Wu,
- John Reagan,
- Usama Gergis,
- Rafael F. Duarte,
- Preet M. Chaudhary,
- Kaixun Hu,
- Changlin Yu,
- Qiyun Sun,
- Ephraim Fuchs,
- Bo Cai,
- Yajing Huang,
- Jianhui Qiao,
- David Gottlieb,
- Kirk R. Schultz,
- Mingyao Liu,
- Xiequn Chen,
- Wenming Chen,
- Jianmin Wang,
- Xiaohui Zhang,
- Jianyong Li,
- He Huang,
- Zimin Sun,
- Fei Li,
- Linhua Yang,
- Liansheng Zhang,
- Lijuan Li,
- Kaiyan Liu,
- Jie Jin,
- Qifa Liu,
- Daihong Liu,
- Chunji Gao,
- Chuanbo Fan,
- Li Wei,
- Xi Zhang,
- Liangding Hu,
- Weijing Zhang,
- Yuyang Tian,
- Weidong Han,
- Jun Zhu,
- Zhijian Xiao,
- Daobin Zhou,
- Bolong Zhang,
- Yongqian Jia,
- Yongqing Zhang,
- Xiaoxiong Wu,
- Xuliang Shen,
- Xuzhang Lu,
- Xinrong Zhan,
- Xiuli Sun,
- Yi Xiao,
- Jingbo Wang,
- Xiaodong Shi,
- Bo Zheng,
- Jieping Chen,
- Banghe Ding,
- Zhao Wang,
- Fan Zhou,
- Mei Zhang,
- Yizhuo Zhang,
- Jie Sun,
- Bing Xia,
- Baoan Chen,
- Liangming Ma
Affiliations
- Huisheng Ai
- Chinese PLA General Hospital, China; Corresponding author. Department of Hematology, The Fifth Medical Center, Chinese PLA General Hospital, 8 Dongdajie Street, Beijing 100071, China.
- Nelson J. Chao
- Duke University, USA; Corresponding author. Division of Hematologic Malignancies and Cellular Therapy/BMT, Global Cancer/Duke Cancer Institute/Duke Global Health Institute, 2400 Pratt St, Suite 5029, Box 3961, Durham, NC 27710, USA.
- David A. Rizzieri
- Novant Health, USA
- Xiaojun Huang
- People's Hospital of Peking University, China
- Thomas R. Spitzer
- Massachusetts General Hospital, USA
- Jianxiang Wang
- Chinese Academy of Medical Sciences Hematology Hospital, China
- Mei Guo
- Chinese PLA General Hospital, China
- Armand Keating
- University of Toronto, Canada
- Elizabeth F. Krakow
- Fred Hutchinson Cancer Research Center, USA
- Didier Blaise
- Marseille Cancer Research Center, France
- Jun Ma
- Harbin Institute of Hematology and Oncology, China
- Depei Wu
- The First Affiliated Hospital of Soochow University, China
- John Reagan
- The Warren Alpert Medical School of Brown University, USA
- Usama Gergis
- Sidney Kimmel Cancer Center, USA
- Rafael F. Duarte
- Hospital Universitario Puerta de Hierro, Spain
- Preet M. Chaudhary
- Keck School of Medicine of University of Southern California, USA
- Kaixun Hu
- Chinese PLA General Hospital, China
- Changlin Yu
- Chinese PLA General Hospital, China
- Qiyun Sun
- Chinese PLA General Hospital, China
- Ephraim Fuchs
- Johns Hopkins University, USA
- Bo Cai
- Chinese PLA General Hospital, China
- Yajing Huang
- Chinese PLA General Hospital, China; Innovvy (Beijing) Biomedical Technology Co.Ltd, China
- Jianhui Qiao
- Chinese PLA General Hospital, China
- David Gottlieb
- Westmead Hospital, Australia
- Kirk R. Schultz
- BC Children's Hospital and Research Institute, Canada
- Mingyao Liu
- University of Toronto, Canada
- Xiequn Chen
- Affiliated Hospital of Northwest University, China
- Wenming Chen
- Beijing Chao-yang Hospital, Capital Medical University, China
- Jianmin Wang
- Changhai Hospital of Naval Medical University, China
- Xiaohui Zhang
- People's Hospital of Peking University, China
- Jianyong Li
- Jiangsu Province Hospital, China
- He Huang
- The First Affiliated Hospital, Zhejiang University School of Medicine, China
- Zimin Sun
- The First Affiliated Hospital of University of Science and Technology of China, China
- Fei Li
- The First Affiliated Hospital of Nanchang University, China
- Linhua Yang
- The Second Hospital of Shanxi Medical University, China
- Liansheng Zhang
- Lanzhou University Second Hospital, China
- Lijuan Li
- Lanzhou University Second Hospital, China
- Kaiyan Liu
- People's Hospital of Peking University, China
- Jie Jin
- The First Affiliated Hospital, Zhejiang University School of Medicine, China
- Qifa Liu
- Nanfang Hospital of Southern Medical University, China
- Daihong Liu
- Chinese PLA General Hospital, China
- Chunji Gao
- Chinese PLA General Hospital, China
- Chuanbo Fan
- Qingdao Hiser Hospital, China
- Li Wei
- Chengdu Fifth People's Hospital, China
- Xi Zhang
- Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Jinfeng Laboratory, China
- Liangding Hu
- Chinese PLA General Hospital, China
- Weijing Zhang
- Beijing Shijitan Hospital, China
- Yuyang Tian
- Hainan Cancer Hospital, China
- Weidong Han
- Chinese PLA General Hospital, China
- Jun Zhu
- Beijing Cancer Hospital, China
- Zhijian Xiao
- Chinese Academy of Medical Sciences Hematology Hospital, China
- Daobin Zhou
- Peking Union Medical College Hospital, China
- Bolong Zhang
- Harbin Institute of Hematology and Oncology, China
- Yongqian Jia
- West China Hospital of Sichuan University, China
- Yongqing Zhang
- Chinese PLA General Hospital, China
- Xiaoxiong Wu
- Chinese PLA General Hospital, China
- Xuliang Shen
- Heping Hospital Affiliated to Changzhi Medical College, China
- Xuzhang Lu
- Changzhou Second People's Hospital, China
- Xinrong Zhan
- Xinxiang Center Hospital, China
- Xiuli Sun
- The First Affiliated Hospital of Dalian Medical University, China
- Yi Xiao
- Tongji Hospital, Tongji Medical College of HUST, China
- Jingbo Wang
- Aerospace Center Hospital, China
- Xiaodong Shi
- Capital Institute of Pediatrics, China
- Bo Zheng
- General Hospital of Ningxia Medical University, China
- Jieping Chen
- Southwest Hospital of Army Medical University, China
- Banghe Ding
- Huai'an First People's Hospital, China
- Zhao Wang
- Beijing Friendship Hospital, Capital Medical University, China
- Fan Zhou
- General Hospital of Northern Theater Command, China
- Mei Zhang
- The First Affiliated Hospital of Xi'an Jiaotong University, China
- Yizhuo Zhang
- Sun Yat-sen University Cancer Center, China
- Jie Sun
- The First Affiliated Hospital, Zhejiang University School of Medicine, China
- Bing Xia
- Tianjin Medical University Cancer Institute and Hospital, China
- Baoan Chen
- Zhongda Hospital, Southeast University, China
- Liangming Ma
- Shanxi Bethune Hospital, China
- Journal volume & issue
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Vol. 9,
no. 4
p. e14924
Abstract
Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, based on analysis of the literature on MST, especially MST with EAML from January 1st, 2011 to November 30th, 2022, the International Microtransplant Interest Group provides recommendations and considerations for MST in the treatment of EAML. Four major issues related to MST for treating EAML were addressed: therapeutic principle of MST (1), candidates for MST (2), induction chemotherapy regimens (3), and post-remission therapy based on MST (4). Others included donor screening, infusion of donor cells, laboratory examinations, and complications of treatment.
