Specific features of endogenic autorosette formation in peripheral blood of patients with pneumonia

Abstract

Aim. To estimate intensity of endogenic autorosette formation in peripheral blood of pneumonia patients and convalescents. Material and methods.Њ The study included 100 patients treated for pneumonia (75 males, 45 females, mean age 48.0±1.0 years) and 40 healthy controls (20 males, 20 females, mean age 47.5±1.1 years). Capillary blood smears stained by Romanovsky-Gimse from all the patients and controls were examined for rosettes (total number of autorosettes, number of autorosettes with exocytic erythrocyte lysis) at admission to hospital, at discharge from hospital and 2-3 weeks after the discharge. Results. The controls had a few autorosettes in the peripheral blood. At admission to hospital pneumonia patients had a much higher level of autorosettes and those with the lysis. At discharge from hospital the number of autorosettes in the patients reduced 1.5 fold, on week 2-3 after the discharge - 2.3 fold but remained high. This reflects a slow attenuation of the inflammation or effects of medication. An increase in the number of autorosettes and autorosettes with lysis is accompanied with a decrease in erythrocyte count and hemoglobin content in the blood. Conclusion. Time course changes in endogenic autorosette formation in peripheral blood can serve an additional marker of pneumonia treatment and rehabilitation efficacy.

Keywords

• endogenic autorosette formation
• autorosette
• pneumonia
• exocytic lysis