Кардиоваскулярная терапия и профилактика (Jan 1970)
Effectiveness of treatment Fluoxetine in female patients at menopause with different form of atrial fibrillation
Abstract
Purpose. To assess effectiveness of fluoxetine treatment of depressive disorders among female patients at menopause in various AF types and impact of this treatment on AF.Materials and methods. The first study group includes 36 female patients with various types of AF and depressive disorders, who took anti-depressant fluoxetine for 6 months period with daily dose of 20 mg. The second reference group includes 34 female patients with various types of AF and major depressive disorder who did not go through treatment of depressive disorders. In both groups the baseline antiarrhythmic therapy has been applied. Evaluation was performed in 6 months after start of treatment. The following has been evaluated: frequency of AF attacks, transition of tachicardic AF type to normocardic AF type and degree of depression as per the questionnaire CESD. Results. Degree of depression intensity who were treated by fluoxetine overall decreased by 3,9 points. Decrease in the rate of depression disorders was accompanied by stop of AF attacks among 12,0 % of the patients and by lower frequency of AF attacks among 64,0 % of the patients with paroxysmal and persistent AF types; transition of tachicardic type to normocardic among 54,5 % of patients with permanent AF type. The most evident clinical effect was observed in the group with paroxysmal and persistent AF types. The least clinical effect of fluoxetine treatment is observed in the group with permanent AF type, which possibly can be explained by more evident degree of heart failure and heavier disease progression.Conclusion. Antidepressant fluoxetine reduces severity of depressive disorders among female patients at menopause with AF, and reduces severity of progression of the various AF types.
