Nature Communications (Jun 2022)
Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity
- Channakeshava Sokke Umeshappa,
- Patricia Solé,
- Jun Yamanouchi,
- Saswat Mohapatra,
- Bas G. J. Surewaard,
- Josep Garnica,
- Santiswarup Singha,
- Debajyoti Mondal,
- Elena Cortés-Vicente,
- Charlotte D’Mello,
- Andrew Mason,
- Paul Kubes,
- Pau Serra,
- Yang Yang,
- Pere Santamaria
Affiliations
- Channakeshava Sokke Umeshappa
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
- Patricia Solé
- Institut D’Investigacions Biomèdiques August Pi i Sunyer
- Jun Yamanouchi
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
- Saswat Mohapatra
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
- Bas G. J. Surewaard
- Department of Physiology and Pharmacology and Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary
- Josep Garnica
- Institut D’Investigacions Biomèdiques August Pi i Sunyer
- Santiswarup Singha
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
- Debajyoti Mondal
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
- Elena Cortés-Vicente
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
- Charlotte D’Mello
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
- Andrew Mason
- Division of Gastroenterology and Hepatology, University of Alberta
- Paul Kubes
- Department of Physiology and Pharmacology and Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary
- Pau Serra
- Institut D’Investigacions Biomèdiques August Pi i Sunyer
- Yang Yang
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
- Pere Santamaria
- Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
- DOI
- https://doi.org/10.1038/s41467-022-30759-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Invariant natural killer T (iNKT) cells are tissue-resident immune cells recognizing lipid antigens. Here the authors find that liver, but not lung nor spleen, iNKT cells alter their transcriptome upon systemic treatment of lipid nanoparticles for the induction of regulatory B cells and suppression of liver and pancreas autoimmunity in mouse models.
