The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors

Lina Liu; Ana Vujovic; Nandan P. Deshpande; Shashank Sathe; Govardhan Anande; He Tian Tony Chen; Joshua Xu; Mark D. Minden; Gene W. Yeo; Ashwin Unnikrishnan; Kristin J. Hope; Yu Lu

doi:10.1038/s41467-022-31155-0

Nature Communications (Jul 2022)

The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors

Lina Liu,
Ana Vujovic,
Nandan P. Deshpande,
Shashank Sathe,
Govardhan Anande,
He Tian Tony Chen,
Joshua Xu,
Mark D. Minden,
Gene W. Yeo,
Ashwin Unnikrishnan,
Kristin J. Hope,
Yu Lu

Affiliations

Lina Liu: Department of Medicine, Faculty of Health Sciences, McMaster University
Ana Vujovic: Department of Medical Biophysics, University of Toronto
Nandan P. Deshpande: Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales
Shashank Sathe: Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego
Govardhan Anande: Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales
He Tian Tony Chen: Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University
Joshua Xu: Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University
Mark D. Minden: Department of Medical Biophysics, University of Toronto
Gene W. Yeo: Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego
Ashwin Unnikrishnan: Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales
Kristin J. Hope: Department of Medical Biophysics, University of Toronto
Yu Lu: Department of Medicine, Faculty of Health Sciences, McMaster University

DOI: https://doi.org/10.1038/s41467-022-31155-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Leukemic stem cells (LSCs) drive chemoresistance and relapse in acute myeloid leukemia. Here, the authors show that the splicing factor RBM17 supports LSCs through avoiding nonsense-mediated decay of pro-leukaemic factors such as the translation initiation factor EIF4A2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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