Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy

Johannes Karges; Shi Kuang; Federica Maschietto; Olivier Blacque; Ilaria Ciofini; Hui Chao; Gilles Gasser

doi:10.1038/s41467-020-16993-0

Nature Communications (Jun 2020)

Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy

Johannes Karges,
Shi Kuang,
Federica Maschietto,
Olivier Blacque,
Ilaria Ciofini,
Hui Chao,
Gilles Gasser

Affiliations

Johannes Karges: Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology
Shi Kuang: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University
Federica Maschietto: Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Theoretical Chemistry and Modelling
Olivier Blacque: Department of Chemistry, University of Zurich
Ilaria Ciofini: Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Theoretical Chemistry and Modelling
Hui Chao: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University
Gilles Gasser: Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology

DOI: https://doi.org/10.1038/s41467-020-16993-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Photosensitizers that are stable in biological conditions with absorption in the biological spectral window are needed for photodynamic therapy. Here, the authors report on the development of a Ruthenium complex for 1 and 2-photon therapy to address these issues and demonstrate application in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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