Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes

Jehyun Jeon; Jaehee Lee; Se-Min Jung; Jae Hong Shin; Woon Ju Song; Mina Rho

doi:10.1128/mSystems.00053-21

mSystems (Jun 2021)

Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes

Jehyun Jeon,
Jaehee Lee,
Se-Min Jung,
Jae Hong Shin,
Woon Ju Song,
Mina Rho

Affiliations

Jehyun Jeon: Department of Computer Science, Hanyang University, Seoul, Republic of Korea
Jaehee Lee: Department of Chemistry, Seoul National University, Seoul, Republic of Korea
Se-Min Jung: Department of Chemistry, Seoul National University, Seoul, Republic of Korea
Jae Hong Shin: Department of Computer Science, Hanyang University, Seoul, Republic of Korea
Woon Ju Song: ORCiD; Department of Chemistry, Seoul National University, Seoul, Republic of Korea
Mina Rho: ORCiD; Department of Computer Science, Hanyang University, Seoul, Republic of Korea

DOI: https://doi.org/10.1128/mSystems.00053-21
Journal volume & issue: Vol. 6, no. 3

Abstract

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Halogenases are playing an important role as tailoring enzymes in biosynthetic pathways. Flavin-dependent tryptophan halogenases (Trp-FDHs) are among the enzymes that have broad substrate scope and high selectivity.

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

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