Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters

Liu Ye; Qiang-Shuai Gu; Yu Tian; Xiang Meng; Guo-Cong Chen; Xin-Yuan Liu

doi:10.1038/s41467-017-02231-7

Nature Communications (Jan 2018)

Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters

Liu Ye,
Qiang-Shuai Gu,
Yu Tian,
Xiang Meng,
Guo-Cong Chen,
Xin-Yuan Liu

Affiliations

Liu Ye: Department of Chemistry, South University of Science and Technology of China
Qiang-Shuai Gu: Department of Chemistry, South University of Science and Technology of China
Yu Tian: Department of Chemistry, South University of Science and Technology of China
Xiang Meng: Department of Chemistry, South University of Science and Technology of China
Guo-Cong Chen: Department of Chemistry, South University of Science and Technology of China
Xin-Yuan Liu: Department of Chemistry, South University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-017-02231-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Synthesis of cyclopropanes bearing vicinal all-carbon quaternary stereocenters poses synthetic challenges. Here, the authors report an intramolecular radical cyclopropanation with a copper/amine cooperative catalytic system for the efficient construction of bicyclo[3.1.0]hexane skeletons, also enantioselectively.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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