Nature Communications (Mar 2023)
Aberrant survival of hippocampal Cajal-Retzius cells leads to memory deficits, gamma rhythmopathies and susceptibility to seizures in adult mice
- Martina Riva,
- Stéphanie Moriceau,
- Annunziato Morabito,
- Elena Dossi,
- Candela Sanchez-Bellot,
- Patrick Azzam,
- Andrea Navas-Olive,
- Beatriz Gal,
- Francesco Dori,
- Elena Cid,
- Fanny Ledonne,
- Sabrina David,
- Fabrice Trovero,
- Magali Bartolomucci,
- Eva Coppola,
- Nelson Rebola,
- Antoine Depaulis,
- Nathalie Rouach,
- Liset Menendez de la Prida,
- Franck Oury,
- Alessandra Pierani
Affiliations
- Martina Riva
- Université Paris Cité, Imagine Institute, Team Genetics and Development of the Cerebral Cortex
- Stéphanie Moriceau
- Platform for Neurobehavioral and metabolism, Structure Fédérative de Recherche Necker, 26 INSERM US24/CNRS UAR
- Annunziato Morabito
- Sorbonne Université, Institut Du Cerveau-Paris Brain Institute-ICM, Inserm U1127, CNRS UMR 7225
- Elena Dossi
- Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Labex Memolife, Université PSL
- Candela Sanchez-Bellot
- Instituto Cajal, CSIC
- Patrick Azzam
- Université Paris Cité, Imagine Institute, Team Genetics and Development of the Cerebral Cortex
- Andrea Navas-Olive
- Instituto Cajal, CSIC
- Beatriz Gal
- Instituto Cajal, CSIC
- Francesco Dori
- Université Paris Cité, Imagine Institute, Team Genetics and Development of the Cerebral Cortex
- Elena Cid
- Instituto Cajal, CSIC
- Fanny Ledonne
- Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266
- Sabrina David
- Key-Obs SAS
- Fabrice Trovero
- Key-Obs SAS
- Magali Bartolomucci
- Université Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences
- Eva Coppola
- Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266
- Nelson Rebola
- Sorbonne Université, Institut Du Cerveau-Paris Brain Institute-ICM, Inserm U1127, CNRS UMR 7225
- Antoine Depaulis
- Université Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences
- Nathalie Rouach
- Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Labex Memolife, Université PSL
- Liset Menendez de la Prida
- Instituto Cajal, CSIC
- Franck Oury
- Université Paris Cité, CNRS, INSERM, Institut Necker Enfants Malades-INEM
- Alessandra Pierani
- Université Paris Cité, Imagine Institute, Team Genetics and Development of the Cerebral Cortex
- DOI
- https://doi.org/10.1038/s41467-023-37249-7
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
Cajal-Retzius neurons number drastically decreases during postnatal life. Here, authors show that their programmed death is required for the construction of functional hippocampal circuits and memory with aberrant survival leading to gamma rhythmopathies and susceptibility to seizures.
