Nutrients (Nov 2017)
The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update
- Carlo Catassi,
- Armin Alaedini,
- Christian Bojarski,
- Bruno Bonaz,
- Gerd Bouma,
- Antonio Carroccio,
- Gemma Castillejo,
- Laura De Magistris,
- Walburga Dieterich,
- Diana Di Liberto,
- Luca Elli,
- Alessio Fasano,
- Marios Hadjivassiliou,
- Matthew Kurien,
- Elena Lionetti,
- Chris J. Mulder,
- Kamran Rostami,
- Anna Sapone,
- Katharina Scherf,
- Detlef Schuppan,
- Nick Trott,
- Umberto Volta,
- Victor Zevallos,
- Yurdagül Zopf,
- David S. Sanders
Affiliations
- Carlo Catassi
- Department of Pediatrics, Marche Polytechnic University, 60121 Ancona, Italy
- Armin Alaedini
- Department of Medicine, Columbia University Medical Center, New York, NY 10027, USA
- Christian Bojarski
- Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité, Campus Benjamin Franklin, 12203 Berlin, Germany
- Bruno Bonaz
- Department of Gastroenterology and Liver Diseases, CHU, 38043 Grenoble, France
- Gerd Bouma
- Celiac Center Amsterdam, Department of Gastroenterology, VU University Medical Center, 1117 Amsterdam, The Netherlands
- Antonio Carroccio
- Department of Internal Medicine, “Giovanni Paolo II” Hospital, Sciacca (AG) and University of Palermo, 92019 Sciacca, Italy
- Gemma Castillejo
- Paediatric Gastroenterology Unit, Sant Joan de Reus University Hospital. IISPV, 43003 Tarragona, Spain
- Laura De Magistris
- Department of Internal and Experimental Medicine Magrassi-Lanzara, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
- Walburga Dieterich
- Medical Clinic 1, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany
- Diana Di Liberto
- Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, 90133 Palermo, Italy
- Luca Elli
- Center for the Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Alessio Fasano
- Center for Celiac Research and Treatment, Massachusetts General Hospital, Boston, MA 02114, USA
- Marios Hadjivassiliou
- Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK
- Matthew Kurien
- Academic Unit of Gastroenterology, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK
- Elena Lionetti
- Department of Pediatrics, Marche Polytechnic University, 60121 Ancona, Italy
- Chris J. Mulder
- Celiac Center Amsterdam, Department of Gastroenterology, VU University Medical Center, 1117 Amsterdam, The Netherlands
- Kamran Rostami
- Gastroenterology Unit, Milton Keynes University Hospital, Milton Keynes MK6 5LD, UK
- Anna Sapone
- Center for Celiac Research and Treatment, Massachusetts General Hospital, Boston, MA 02114, USA
- Katharina Scherf
- German Research Centre for Food Chemistry, Leibniz Institute, Lise-Meitner-Straße 34, D-85354 Freising, Germany
- Detlef Schuppan
- Institute of Translational Immunology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
- Nick Trott
- Academic Unit of Gastroenterology, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK
- Umberto Volta
- Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
- Victor Zevallos
- Institute of Translational Immunology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
- Yurdagül Zopf
- Medical Clinic 1, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany
- David S. Sanders
- Academic Unit of Gastroenterology, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK
- DOI
- https://doi.org/10.3390/nu9111268
- Journal volume & issue
-
Vol. 9,
no. 11
p. 1268
Abstract
Gluten-related disorders have recently been reclassified with an emerging scientific literature supporting the concept of non-celiac gluten sensitivity (NCGS). New research has specifically addressed prevalence, immune mechanisms, the recognition of non-immunoglobulin E (non-IgE) wheat allergy and overlap of NCGS with irritable bowel syndrome (IBS)-type symptoms. This review article will provide clinicians with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion.
Keywords
- gluten sensitivity
- celiac disease
- wheat allergy
- gluten-related disorders
- gluten-free diet
- amylase-trypsin inhibitors (ATIs)
