P160 VASCULAR ABNORMALITIES AND HAEMODYNAMIC PATTERN IN OBESE YOUNG ADULTS

Abstract

Background: Obesity is linked to a higher prevalence of risk factors, metabolic and inflammatory pathways conducting to increased vascular disease and CV risk. Objective: To assess vascular disarrangements and haemodynamic patterns in obese young subjects (O) compared with matched lean (L) controls, using non invasive methods. Methods: From the database of our Non Invasive Vascular Lab with 3964 first evaluated patients, we performed a case control study with 363 sujects, 268 obese and 95 lean, age and sex matched controls. We measured IMT, Plaque analysis, PWV, Endothelial Function (EF) and arterial stiffness (CAP and Aix) (AS) using an oscillometric device (Arteriograph, Tensiomed. Hungary®) and non invasive haemodynamic evaluation using impedance cardiography (Z Logic Exxer®). Results: Age (O 42.5 + 5; L 43.5 + 11) and sex % (O 80.6%; L 78%) were matched. BMI (O 33.5 + 3.3 L 25 + 1.1Kg/m2), waist (O110.4 + 7.5; L 91.2 + 6.1cm) and BP (SBP O 139.8 + 16.8; L119 + 8.8 and DBP O 89 + 3.9; L 74.3 + 8 mmHg) were higher in O (p < 0.001).CV Risk Factors in O: HTN 68% DLP 59.7% SMKG 24.2% DBT2 7.8% SED 72.4%.The % of abnormalities in IMT (O/L : 65.8/25.3%), Plaques (75.6/38.9%), EF (57.5/33.7%) and PWV (41.4/17.9%) were higher in O (p < 0.001). Central and Peripheral PP were higher in O but not Aix. CI was significantly lower and PVRI and Thoracic Fluid content higher in O. Conclusion: Young obese patients present a higher prevalence of vascular disarrangements either structural and functional and a haemodynamic pattern of high peripheral resistance with volume expansion that may explain the role of this condition as a CV risk factor.