Features of calcium signaling in ischemic injury nervous tissue – of neurons in the hippocampus

Abstract

This review describes the features of the systems to ensure the restoration of calcium homeostasis of hippocampal neurons during ischemic injury. High levels of intracellular Ca 2+ , glutamate excitotoxicity activity and the formation of free radicals during ischemia are a major damaging factors, leading to further damage to hippocampal neurons. Understanding the mechanisms able to prevent the development of damage today is key for the development of post- and preconditioning neuroprotective strategies.

Keywords

• SERCA – Ca2+-ATPase of endoplasmic reticulum, PMCA – Ca2+ATP-ASE of plasmatic membrane, ischemic injury, the hippocampus