Nature Communications (Dec 2019)
Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent
- Christopher Hübel,
- Héléna A. Gaspar,
- Jonathan R. I. Coleman,
- Ken B. Hanscombe,
- Kirstin Purves,
- Inga Prokopenko,
- Mariaelisa Graff,
- Julius S. Ngwa,
- Tsegaselassie Workalemahu,
- ADHD Working Group of the Psychiatric Genomics Consortium,
- Meta-Analyses of Glucose and Insulin-related traits consortium (MAGIC),
- Autism Working Group of the Psychiatric Genomics Consortium,
- Bipolar Disorder Working Group of the Psychiatric Genomics Consortium,
- Eating Disorders Working Group of the Psychiatric Genomics Consortium,
- Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium,
- OCD & Tourette Syndrome Working Group of the Psychiatric Genomics Consortium,
- PTSD Working Group of the Psychiatric Genomics Consortium,
- Schizophrenia Working Group of the Psychiatric Genomics Consortium,
- Sex Differences Cross Disorder Working Group of the Psychiatric Genomics Consortium,
- Substance Use Disorders Working Group of the Psychiatric Genomics Consortium,
- German Borderline Genomics Consortium,
- International Headache Genetics Consortium,
- Paul F. O’Reilly,
- Cynthia M. Bulik,
- Gerome Breen
Affiliations
- Christopher Hübel
- Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Héléna A. Gaspar
- Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Jonathan R. I. Coleman
- Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Ken B. Hanscombe
- Department of Medical and Molecular Genetics, King’s College London, Guy’s Hospital
- Kirstin Purves
- Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Inga Prokopenko
- Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey
- Mariaelisa Graff
- Department of Epidemiology, University of North Carolina
- Julius S. Ngwa
- Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
- Tsegaselassie Workalemahu
- Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
- ADHD Working Group of the Psychiatric Genomics Consortium
- Meta-Analyses of Glucose and Insulin-related traits consortium (MAGIC)
- Autism Working Group of the Psychiatric Genomics Consortium
- Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
- Eating Disorders Working Group of the Psychiatric Genomics Consortium
- Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
- OCD & Tourette Syndrome Working Group of the Psychiatric Genomics Consortium
- PTSD Working Group of the Psychiatric Genomics Consortium
- Schizophrenia Working Group of the Psychiatric Genomics Consortium
- Sex Differences Cross Disorder Working Group of the Psychiatric Genomics Consortium
- Substance Use Disorders Working Group of the Psychiatric Genomics Consortium
- German Borderline Genomics Consortium
- International Headache Genetics Consortium
- Paul F. O’Reilly
- Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Cynthia M. Bulik
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Gerome Breen
- Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- DOI
- https://doi.org/10.1038/s41467-019-13544-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Psychiatric disorders are often accompanied by alterations in BMI and body composition due to changes in eating behaviour and physical activity. Here, Hübel et al. study the genetic overlap between these traits and find that genetic correlations between psychiatric disorders and body composition are sex-specific and evident only in adulthood.
