mBio (Apr 2021)

Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP <sup>C</sup> and Other Host-Specific Factors

  • Juan Carlos Espinosa,
  • Olivier Andreoletti,
  • Alba Marín-Moreno,
  • Severine Lugan,
  • Patricia Aguilar-Calvo,
  • Hervé Cassard,
  • Patricia Lorenzo,
  • Jean-Yves Douet,
  • Ana Villa-Díaz,
  • Naima Aron,
  • Irene Prieto,
  • Alvina Huor,
  • Juan María Torres

DOI
https://doi.org/10.1128/mBio.03508-20
Journal volume & issue
Vol. 12, no. 2

Abstract

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Prion propagation can be interfered with by the expression of a second prion protein in the host. In the present study, we investigated prion propagation in a host expressing two different prion protein genes.