Frontiers in Bioengineering and Biotechnology (Mar 2021)

SAXS/WAXS Investigation of Amyloid-β(16-22) Peptide Nanotubes

  • Theyencheri Narayanan,
  • Axel Rüter,
  • Ulf Olsson

DOI
https://doi.org/10.3389/fbioe.2021.654349
Journal volume & issue
Vol. 9

Abstract

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This brief report presents an X-ray scattering investigation of self-assembled nanotubes formed by a short peptide. X-ray scattering methods enable multiscale structural elucidation of these nanotubes in solution under the same conditions involved in the self-assembly process. In particular, the dimensions of nanotubes and the crystalline organization within their walls can be determined quantitatively. This is illustrated in the case of amyloid-β(16-22) peptide nanotubes.

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