Nature Communications (Jan 2022)
Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis
- Markus Scholz,
- Katrin Horn,
- Janne Pott,
- Arnd Gross,
- Marcus E. Kleber,
- Graciela E. Delgado,
- Pashupati Prasad Mishra,
- Holger Kirsten,
- Christian Gieger,
- Martina Müller-Nurasyid,
- Anke Tönjes,
- Peter Kovacs,
- Terho Lehtimäki,
- Olli Raitakari,
- Mika Kähönen,
- Helena Gylling,
- Ronny Baber,
- Berend Isermann,
- Michael Stumvoll,
- Markus Loeffler,
- Winfried März,
- Thomas Meitinger,
- Annette Peters,
- Joachim Thiery,
- Daniel Teupser,
- Uta Ceglarek
Affiliations
- Markus Scholz
- Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig
- Katrin Horn
- Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig
- Janne Pott
- Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig
- Arnd Gross
- Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig
- Marcus E. Kleber
- Medical Faculty Mannheim, Vth Department of Medicine, Heidelberg University
- Graciela E. Delgado
- Medical Faculty Mannheim, Vth Department of Medicine, Heidelberg University
- Pashupati Prasad Mishra
- Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University
- Holger Kirsten
- Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Martina Müller-Nurasyid
- Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Anke Tönjes
- Medical Department III – Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig
- Peter Kovacs
- German Center for Diabetes Research (DZD)
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University
- Olli Raitakari
- Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University
- Helena Gylling
- Department of Internal Medicine, University of Helsinki and Helsinki University Hospital
- Ronny Baber
- LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig
- Berend Isermann
- Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig
- Michael Stumvoll
- Medical Department III – Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig
- Markus Loeffler
- Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig
- Winfried März
- Medical Faculty Mannheim, Vth Department of Medicine, Heidelberg University
- Thomas Meitinger
- Institue for Human Genetics, Technical University of Munich
- Annette Peters
- Institue of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Joachim Thiery
- LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig
- Daniel Teupser
- Insitute for Laboratory Medicine, Ludwig-Maximilians University of Munich
- Uta Ceglarek
- LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig
- DOI
- https://doi.org/10.1038/s41467-021-27706-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Physterols are cholesterol homologs derived from plants, which are found in humans through consumption of plant products. Here the authors have performed a genome-wide meta-analysis of 32 serum phytosterol traits, with evidence suggesting causality between sitosterol and coronary artery disease.
