Nature Communications (Mar 2022)
Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics
- P. S. Ramachandran,
- A. Ramesh,
- F. V. Creswell,
- A. Wapniarski,
- R. Narendra,
- C. M. Quinn,
- E. B. Tran,
- M. K. Rutakingirwa,
- A. S. Bangdiwala,
- E. Kagimu,
- K. T. Kandole,
- K. C. Zorn,
- L. Tugume,
- J. Kasibante,
- K. Ssebambulidde,
- M. Okirwoth,
- N. C. Bahr,
- A. Musubire,
- C. P. Skipper,
- C. Fouassier,
- A. Lyden,
- P. Serpa,
- G. Castaneda,
- S. Caldera,
- V. Ahyong,
- J. L. DeRisi,
- C. Langelier,
- E. D. Crawford,
- D. R. Boulware,
- D. B. Meya,
- M. R. Wilson
Affiliations
- P. S. Ramachandran
- Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco
- A. Ramesh
- Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco
- F. V. Creswell
- Clinical Research Department, London School of Hygiene and Tropical Medicine
- A. Wapniarski
- Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco
- R. Narendra
- Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco
- C. M. Quinn
- University of California School of Medicine
- E. B. Tran
- University of California School of Medicine
- M. K. Rutakingirwa
- Infectious Diseases Institute, Makerere University
- A. S. Bangdiwala
- University of Minnesota
- E. Kagimu
- Infectious Diseases Institute, Makerere University
- K. T. Kandole
- Infectious Diseases Institute, Makerere University
- K. C. Zorn
- UCSF Center for Encephalitis and Meningitis
- L. Tugume
- Infectious Diseases Institute, Makerere University
- J. Kasibante
- Infectious Diseases Institute, Makerere University
- K. Ssebambulidde
- Infectious Diseases Institute, Makerere University
- M. Okirwoth
- Infectious Diseases Institute, Makerere University
- N. C. Bahr
- Division of Infectious Diseases, Department of Medicine, University of Kansas
- A. Musubire
- Infectious Diseases Institute, Makerere University
- C. P. Skipper
- Infectious Diseases Institute, Makerere University
- C. Fouassier
- Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco
- A. Lyden
- Chan Zuckerberg Biohub
- P. Serpa
- Chan Zuckerberg Biohub
- G. Castaneda
- Chan Zuckerberg Biohub
- S. Caldera
- Chan Zuckerberg Biohub
- V. Ahyong
- Chan Zuckerberg Biohub
- J. L. DeRisi
- UCSF Center for Encephalitis and Meningitis
- C. Langelier
- Chan Zuckerberg Biohub
- E. D. Crawford
- Chan Zuckerberg Biohub
- D. R. Boulware
- University of Minnesota
- D. B. Meya
- Infectious Diseases Institute, Makerere University
- M. R. Wilson
- Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco
- DOI
- https://doi.org/10.1038/s41467-022-29353-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Tuberculous meningitis is difficult to differentiate from meningitis caused by other pathogens. Here, the authors combine metagenomics-based pathogen detection in cerebrospinal fluid with a host gene expression-based machine learning classifier for diagnosis.
