Association of the systemic inflammation and anthropometric measurements with cancer risk: a prospective study in MJ cohort

Zilong Bian; Luopiao Xu; Yuting Wang; Min-Kuang Tsai; David Ta-Wei Chu; Huakang Tu; Chi-Pang Wen; Xifeng Wu; Xifeng Wu; Xifeng Wu

doi:10.3389/fonc.2024.1400893

Frontiers in Oncology (Sep 2024)

Association of the systemic inflammation and anthropometric measurements with cancer risk: a prospective study in MJ cohort

Zilong Bian,
Luopiao Xu,
Yuting Wang,
Min-Kuang Tsai,
David Ta-Wei Chu,
Huakang Tu,
Chi-Pang Wen,
Xifeng Wu,
Xifeng Wu,
Xifeng Wu

Affiliations

Zilong Bian: Department of Big Data in Health Science School of Public Health, and Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Luopiao Xu: Department of Big Data in Health Science School of Public Health, and Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Yuting Wang: Department of Big Data in Health Science School of Public Health, and Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Min-Kuang Tsai: Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
David Ta-Wei Chu: MJ Health Management Center, Taipei, Taiwan
Huakang Tu: Department of Big Data in Health Science School of Public Health, and Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Chi-Pang Wen: National Institute for Data Science in Health and Medicine, Zhejiang University, Hangzhou, China
Xifeng Wu: Department of Big Data in Health Science School of Public Health, and Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Xifeng Wu: National Institute for Data Science in Health and Medicine, Zhejiang University, Hangzhou, China
Xifeng Wu: School of Medicine and Health Science, George Washington University, Washington DC, United States

DOI: https://doi.org/10.3389/fonc.2024.1400893
Journal volume & issue: Vol. 14

Abstract

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ObjectiveTo investigate the specific role of inflammation in the connection between obesity and the overall incidence of cancer.MethodsA total of 356,554 participants in MJ cohort study were included. Systemic inflammation markers from blood samples and anthropometric measurements were determined using professional instruments. The Cox model was adopted to evaluate the association.ResultsOver a median follow-up of 8.2 years, 9,048 cancer cases were identified. For individual systemic inflammation biomarkers, the overall cancer risk significantly escalated as blood C-reactive protein (CRP) (hazard ratio (HR)=1.036 (1.017-1.054)) and globulin (GLO) (HR=1.128 (1.105-1.152)) levels increased, and as hemoglobin (HEMO) (HR=0.863 (0.842-0.884)), albumin (ALB) (HR=0.846 (0.829-0.863)) and platelets (PLA) (HR=0.842 (0.827-0.858)) levels decreased. For composite indicators, most of them existed a significant relationship to the overall cancer risk. Most indicators were correlated with the overall cancer and obesity-related cancer risk, but there was a reduction of association with non-obesity related cancer risk. Most of indicators mediated the association between anthropometric measurements and overall cancer risk.ConclusionsSystemic inflammatory state was significantly associated with increased risks of cancer risk. Inflammation biomarkers were found to partly mediate the association between obesity and cancer risk.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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