Noliprel and endothelial dysfunction correction in metabolic syndrome patients

Abstract

Aim. To study endothelial functional status dynamics in metabolic syndrome (MS) patients receiving Noliprel® therapy. Material and methods. In 39 patients with diagnosed MS, endothelial functional status (reactive hyperemia and nitroglycerin tests), microcirculation (MC) and 24-hour blood pressure monitoring (BPM) parameters were assessed during 6-month Noliprel ® therapy. Results. After 6 month of Noliprel® therapy, systolic and diastolic BP levels significantly decreased (р<0.01 and р<0.05, respectively), 24-hour BPM parameters improved. Endothelium-dependent vasodilatation increased, that was a symptom of endothelial function improvement. MC parameters also improved, initially reduced prostacyclin level increased (р<0.01), and initially increased thromboxane concentration decreased (р<0.01). Microalbuminuria and proteinuria levels significantly reduced (р<0.01). Conclusion. Noliprel® improved endothelial function in MS patients. Endothelial dysfunction correction changed vascular reactivity to vasoconstrictors, regardless of vessel size, and therefore, improved hemodynamic and hemostatic parameters.

Keywords

• metabolic syndrome
• therapy
• noliprel®
• endothelial dysfunction