Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

Hong-pyo Lee; Ryan Stowers; Ovijit Chaudhuri

doi:10.1038/s41467-019-08465-x

Nature Communications (Jan 2019)

Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

Hong-pyo Lee,
Ryan Stowers,
Ovijit Chaudhuri

Affiliations

Hong-pyo Lee: Department of Mechanical Engineering, Stanford University
Ryan Stowers: Department of Mechanical Engineering, Stanford University
Ovijit Chaudhuri: Department of Mechanical Engineering, Stanford University

DOI: https://doi.org/10.1038/s41467-019-08465-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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For mesenchymal stem cells (MSCs), matrix remodeling is associated with enhanced osteogenic differentiation. Here authors find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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