Current Insights into Long Non-Coding RNAs in Renal Cell Carcinoma

Maximilian Seles; Georg C. Hutterer; Tobias Kiesslich; Karl Pummer; Ioana Berindan-Neagoe; Samantha Perakis; Daniela Schwarzenbacher; Michael Stotz; Armin Gerger; Martin Pichler

doi:10.3390/ijms17040573

International Journal of Molecular Sciences (Apr 2016)

Current Insights into Long Non-Coding RNAs in Renal Cell Carcinoma

Maximilian Seles,
Georg C. Hutterer,
Tobias Kiesslich,
Karl Pummer,
Ioana Berindan-Neagoe,
Samantha Perakis,
Daniela Schwarzenbacher,
Michael Stotz,
Armin Gerger,
Martin Pichler

Affiliations

Maximilian Seles: Department of Urology, Medical University of Graz, A-8036 Graz, Austria
Georg C. Hutterer: Department of Urology, Medical University of Graz, A-8036 Graz, Austria
Tobias Kiesslich: Department of Internal Medicine I, Salzburger Landeskliniken (SALK), Paracelsus Medical University, A-5020 Salzburg, Austria
Karl Pummer: Department of Urology, Medical University of Graz, A-8036 Graz, Austria
Ioana Berindan-Neagoe: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
Samantha Perakis: Institute of Human Genetics, Medical University of Graz, A-8036 Graz, Austria
Daniela Schwarzenbacher: Division of Oncology, Department of Internal Medicine, Medical University of Graz, A-8036 Graz, Austria
Michael Stotz: Division of Oncology, Department of Internal Medicine, Medical University of Graz, A-8036 Graz, Austria
Armin Gerger: Division of Oncology, Department of Internal Medicine, Medical University of Graz, A-8036 Graz, Austria
Martin Pichler: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA

DOI: https://doi.org/10.3390/ijms17040573
Journal volume & issue: Vol. 17, no. 4
p. 573

Abstract

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Renal cell carcinoma (RCC) represents a deadly disease with rising mortality despite intensive therapeutic efforts. It comprises several subtypes in terms of distinct histopathological features and different clinical presentations. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts in the genome which vary in expression levels and length and perform diverse functions. They are involved in the inititation, evolution and progression of primary cancer, as well as in the development and spread of metastases. Recently, several lncRNAs were described in RCC. This review emphasises the rising importance of lncRNAs in RCC. Moreover, it provides an outlook on their therapeutic potential in the future.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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Abstract

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