New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

Abstract

Abstract Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3–10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were established on the basis of spectroscopic data interpretation, single crystal X-ray diffraction analysis and circular dichroism spectrum. Graphic Abstract

Keywords

• Tabernaemontana divaricata
• Iboga-type indole alkaloid
• Single crystal X-ray diffraction