Vaccines (Jan 2023)

Predictive Value of Reactogenicity for Anti-SARS-CoV-2 Antibody Response in mRNA-1273 Recipients: A Multicenter Prospective Cohort Study

  • Min Joo Choi,
  • Jung Yeon Heo,
  • Yu Bin Seo,
  • Young Kyung Yoon,
  • Jang Wook Sohn,
  • Ji Yun Noh,
  • Hee Jin Cheong,
  • Woo Joo Kim,
  • Ju-yeon Choi,
  • Young Jae Lee,
  • Hye Won Lee,
  • Sung Soon Kim,
  • Byoungguk Kim,
  • Joon Young Song

DOI
https://doi.org/10.3390/vaccines11010120
Journal volume & issue
Vol. 11, no. 1
p. 120

Abstract

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Messenger RNA (mRNA) vaccination was developed to mitigate the coronavirus disease 2019 pandemic. However, data on antibody kinetics and factors influencing these vaccines’ immunogenicity are limited. We conducted a prospective study on healthy young adults who received two doses of the mRNA-1273 vaccine at 28-day intervals. After each dose, adverse events were prospectively evaluated, and blood samples were collected. The correlation between humoral immune response and reactogenicity after vaccination was determined. In 177 participants (19–55 years), the geometric mean titers of anti-S IgG antibody were 178.07 and 4409.61 U/mL, while those of 50% neutralizing titers were 479.95 and 2851.67 U/mL four weeks after the first and second vaccine doses, respectively. Anti-S IgG antibody titers were not associated with local reactogenicity but were higher in participants who experienced systemic adverse events (headache and muscle pain). Antipyretic use was an independent predictive factor of a robust anti-SARS-CoV-2 antibody response after receiving both vaccine doses. Systemic reactogenicity after the first dose influenced antibody response after the second dose. In conclusion, mRNA-1273 induced a robust antibody response in healthy young adults. Antipyretic use did not decrease the anti-SARS-CoV-2 antibody response after mRNA-1273 vaccination.

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