FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

Vijayashree Mysore; Xavier Cullere; Joseph Mears; Florencia Rosetti; Koshu Okubo; Pei X. Liew; Fan Zhang; Iris Madera-Salcedo; Frank Rosenbauer; Richard M. Stone; Jon C. Aster; Ulrich H. von Andrian; Andrew H. Lichtman; Soumya Raychaudhuri; Tanya N. Mayadas

doi:10.1038/s41467-021-24591-x

Nature Communications (Aug 2021)

FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

Vijayashree Mysore,
Xavier Cullere,
Joseph Mears,
Florencia Rosetti,
Koshu Okubo,
Pei X. Liew,
Fan Zhang,
Iris Madera-Salcedo,
Frank Rosenbauer,
Richard M. Stone,
Jon C. Aster,
Ulrich H. von Andrian,
Andrew H. Lichtman,
Soumya Raychaudhuri,
Tanya N. Mayadas

Affiliations

Vijayashree Mysore: Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Xavier Cullere: Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Joseph Mears: Center for Data Sciences, Brigham and Women’s Hospital
Florencia Rosetti: Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Koshu Okubo: Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Pei X. Liew: Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Fan Zhang: Center for Data Sciences, Brigham and Women’s Hospital
Iris Madera-Salcedo: Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Frank Rosenbauer: Institute of Molecular Tumor Biology, University of Muenster
Richard M. Stone: Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
Jon C. Aster: Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Ulrich H. von Andrian: Department of Microbiology and Immunobiology, Harvard Medical School
Andrew H. Lichtman: Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Soumya Raychaudhuri: Center for Data Sciences, Brigham and Women’s Hospital
Tanya N. Mayadas: Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-021-24591-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 23

Abstract

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Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable functions as classical dendritic cells, and with therapeutic potentials for cancer and infectious diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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