Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile

Maria Giovanna Lupo; Diletta Arcidiacono; Alice Zaramella; Fabio Fimiani; Paolo Calabrò; Angelo Baldassare Cefalù; Maurizio Averna; Laura D'Erasmo; Marcello Arca; Sara De Martin; Alberto Zambon; Nicola Ferri

Atherosclerosis Plus (Sep 2021)

Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile

Maria Giovanna Lupo,
Diletta Arcidiacono,
Alice Zaramella,
Fabio Fimiani,
Paolo Calabrò,
Angelo Baldassare Cefalù,
Maurizio Averna,
Laura D'Erasmo,
Marcello Arca,
Sara De Martin,
Alberto Zambon,
Nicola Ferri

Affiliations

Maria Giovanna Lupo: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padua, Italy
Diletta Arcidiacono: Digestive Endoscopy Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
Alice Zaramella: Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; Istituto Oncologico Veneto IOV-IRCCS, Padova, Italia
Fabio Fimiani: A.O.R.N. Sant’Anna e San Sebastiano, Caserta Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy
Paolo Calabrò: A.O.R.N. Sant’Anna e San Sebastiano, Caserta Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy
Angelo Baldassare Cefalù: Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy
Maurizio Averna: Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy
Laura D'Erasmo: Department of Translational and Precision Medicine, Sapienza, University of Rome, Rome, Italy
Marcello Arca: Department of Translational and Precision Medicine, Sapienza, University of Rome, Rome, Italy
Sara De Martin: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padua, Italy
Alberto Zambon: Department of Medicine, University of Padova, Padua, Italy
Nicola Ferri: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padua, Italy; Corresponding author. Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Largo Egidio Meneghetti 2, 35131, Padua, Italy.

Journal volume & issue: Vol. 43
pp. 7 – 9

Abstract

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Lomitapide, a drug for the treatment of homozygous familial hypercholesterolemia patients, reduced total and LDL cholesterol but no significant changes were observed on PCSK9 and Lp(a) plasma levels. Some changes of inflammatory mediators were also observed, including hsCRP, which may suggest an anti-inflammatory effect.

Published in Atherosclerosis Plus

ISSN: 2667-0895 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/atherosclerosis-plus

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