Frontiers in Immunology (Mar 2022)
Distinct Immune Response at 1 Year Post-COVID-19 According to Disease Severity
- Chang Kyung Kang,
- Minji Kim,
- Minji Kim,
- Minji Kim,
- Jisu Hong,
- Jisu Hong,
- Jisu Hong,
- Gwanghun Kim,
- Gwanghun Kim,
- Gwanghun Kim,
- Soojin Lee,
- Soojin Lee,
- Soojin Lee,
- Euijin Chang,
- Pyoeng Gyun Choe,
- Nam Joong Kim,
- Ik Soo Kim,
- Jun-Young Seo,
- Jun-Young Seo,
- Daesub Song,
- Dong-Sup Lee,
- Dong-Sup Lee,
- Dong-Sup Lee,
- Dong-Sup Lee,
- Dong-Sup Lee,
- Hyun Mu Shin,
- Hyun Mu Shin,
- Hyun Mu Shin,
- Yong-Woo Kim,
- Chang-Han Lee,
- Chang-Han Lee,
- Chang-Han Lee,
- Chang-Han Lee,
- Wan Beom Park,
- Hang-Rae Kim,
- Hang-Rae Kim,
- Hang-Rae Kim,
- Hang-Rae Kim,
- Hang-Rae Kim,
- Myoung-don Oh
Affiliations
- Chang Kyung Kang
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
- Minji Kim
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Minji Kim
- Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul, South Korea
- Minji Kim
- BrainKorea21 (BK21) FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, South Korea
- Jisu Hong
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Jisu Hong
- BrainKorea21 (BK21) FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, South Korea
- Jisu Hong
- Department of Pharmacology, Seoul National University College of Medicine, Seoul, South Korea
- Gwanghun Kim
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Gwanghun Kim
- Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul, South Korea
- Gwanghun Kim
- BrainKorea21 (BK21) FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, South Korea
- Soojin Lee
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Soojin Lee
- Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul, South Korea
- Soojin Lee
- BrainKorea21 (BK21) FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, South Korea
- Euijin Chang
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
- Pyoeng Gyun Choe
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
- Nam Joong Kim
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
- Ik Soo Kim
- Department of Microbiology, School of Medicine, Gachon University, Incheon, South Korea
- Jun-Young Seo
- Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea
- Jun-Young Seo
- BrainKorea21 (BK21) Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
- Daesub Song
- College of Pharmacy, Korea University, Sejong, South Korea
- Dong-Sup Lee
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Dong-Sup Lee
- Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul, South Korea
- Dong-Sup Lee
- BrainKorea21 (BK21) FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, South Korea
- Dong-Sup Lee
- 0Medical Research Institute, Seoul National University College of Medicine, Seoul, South Korea
- Dong-Sup Lee
- 1Wide River Institute of Immunology, Seoul National University, Hongcheon, South Korea
- Hyun Mu Shin
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Hyun Mu Shin
- BrainKorea21 (BK21) FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, South Korea
- Hyun Mu Shin
- 1Wide River Institute of Immunology, Seoul National University, Hongcheon, South Korea
- Yong-Woo Kim
- 1Wide River Institute of Immunology, Seoul National University, Hongcheon, South Korea
- Chang-Han Lee
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Chang-Han Lee
- BrainKorea21 (BK21) FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, South Korea
- Chang-Han Lee
- Department of Pharmacology, Seoul National University College of Medicine, Seoul, South Korea
- Chang-Han Lee
- 1Wide River Institute of Immunology, Seoul National University, Hongcheon, South Korea
- Wan Beom Park
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
- Hang-Rae Kim
- Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
- Hang-Rae Kim
- Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul, South Korea
- Hang-Rae Kim
- BrainKorea21 (BK21) FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, South Korea
- Hang-Rae Kim
- 0Medical Research Institute, Seoul National University College of Medicine, Seoul, South Korea
- Hang-Rae Kim
- 1Wide River Institute of Immunology, Seoul National University, Hongcheon, South Korea
- Myoung-don Oh
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
- DOI
- https://doi.org/10.3389/fimmu.2022.830433
- Journal volume & issue
-
Vol. 13
Abstract
BackgroundDespite the fact of ongoing worldwide vaccination programs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), understanding longevity, breadth, and type of immune response to coronavirus disease-19 (COVID-19) is still important to optimize the vaccination strategy and estimate the risk of reinfection. Therefore, we performed thorough immunological assessments 1 year post-COVID-19 with different severity.MethodsWe analyzed peripheral blood mononuclear cells and plasma samples at 1 year post-COVID-19 in patients who experienced asymptomatic, mild, and severe illness to assess titers of various isotypes of antibodies (Abs) against SARS-CoV-2 antigens, phagocytic capability, and memory B- and T-cell responses.FindingsA total of 24 patients (7, 9, and 8 asymptomatic, mild, and severe patients, respectively) and eight healthy volunteers were included in this study. We firstly showed that disease severity is correlated with parameters of immune responses at 1 year post-COVID-19 that play an important role in protecting against reinfection with SARS-CoV-2, namely, the phagocytic capacity of Abs and memory B-cell responses.InterpretationVarious immune responses at 1 year post-COVID-19, particularly the phagocytic capacity and memory B-cell responses, were dependent on the severity of the prior COVID-19. Our data could provide a clue for a tailored vaccination strategy after natural infection according to the severity of COVID-19.
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