Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology

Max Lam; Chia-Yen Chen; W. David Hill; Charley Xia; Ruoyu Tian; Daniel F. Levey; Joel Gelernter; Murray B. Stein; Alexander S. Hatoum; Hailiang Huang; Anil K. Malhotra; Heiko Runz; Tian Ge; Todd Lencz

doi:10.1038/s41467-022-34418-y

Nature Communications (Nov 2022)

Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology

Max Lam,
Chia-Yen Chen,
W. David Hill,
Charley Xia,
Ruoyu Tian,
Daniel F. Levey,
Joel Gelernter,
Murray B. Stein,
Alexander S. Hatoum,
Hailiang Huang,
Anil K. Malhotra,
Heiko Runz,
Tian Ge,
Todd Lencz

Affiliations

Max Lam: Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell
Chia-Yen Chen: Translational Biology, Research and Development, Biogen Inc
W. David Hill: Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh
Charley Xia: Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh
Ruoyu Tian: Computational Biology and Human Genetics, Dewpoint Therapeutics
Daniel F. Levey: Department of Psychiatry, Yale University School of Medicine
Joel Gelernter: Department of Psychiatry, Yale University School of Medicine
Murray B. Stein: VA San Diego Healthcare System
Alexander S. Hatoum: Department of Psychiatry, Washington University in St. Louis Medical School
Hailiang Huang: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
Anil K. Malhotra: Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell
Heiko Runz: Translational Biology, Research and Development, Biogen Inc
Tian Ge: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
Todd Lencz: Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell

DOI: https://doi.org/10.1038/s41467-022-34418-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 22

Abstract

Read online

Cognitive impairments are a key feature of psychopathology. Here, authors exploit the genetic overlap between cognitive dimensions and psychopathology to parse the biology of psychiatric illness and identify “meta-loci” genome segments characterized by specific patterns of overlap.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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