Environment International (Sep 2019)
Agricultural exposures to carbamate herbicides and fungicides and central nervous system tumour incidence in the cohort AGRICAN
- Clément Piel,
- Camille Pouchieu,
- Camille Carles,
- Béatrix Béziat,
- Mathilde Boulanger,
- Mathilde Bureau,
- Amandine Busson,
- Anne Grüber,
- Yannick Lecluse,
- Lucile Migault,
- Marine Renier,
- Virginie Rondeau,
- Xavier Schwall,
- Séverine Tual,
- Lebailly Pierre,
- Isabelle Baldi,
- P. Arveux,
- S. Bara,
- A.M. Bouvier,
- T. Busquet,
- M. Colonna,
- G. Coureau,
- M. Delanoé,
- P. Grosclaude,
- A.V. Guizard,
- P. Herbrecht,
- J.J. Laplante,
- B. Lapotre-Ledoux,
- G. Launoy,
- D. Lenoir,
- E. Marrer,
- E. Marcotullio,
- M. Maynadié,
- F. Molinié,
- A. Monnereau,
- A. Paumier,
- P. Pouzet,
- J.M. Thibaudier,
- X. Troussard,
- M. Velten,
- E. Wavelet,
- A.S. Woronoff
Affiliations
- Clément Piel
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
- Camille Pouchieu
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France; Registre des tumeurs primitives du système nerveux central de la Gironde, ISPED, Centre INSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
- Camille Carles
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France; CHU de Bordeaux, Service de Médecine du Travail et Pathologies Professionnelles, Bordeaux, France
- Béatrix Béziat
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
- Mathilde Boulanger
- INSERM, U1086 Anticipe Axe Cancers et Préventions, Caen, France; Université de Caen Normandie, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, Caen, France
- Mathilde Bureau
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
- Amandine Busson
- INSERM, U1086 Anticipe Axe Cancers et Préventions, Caen, France; Université de Caen Normandie, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, Caen, France
- Anne Grüber
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France; Registre des tumeurs primitives du système nerveux central de la Gironde, ISPED, Centre INSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
- Yannick Lecluse
- INSERM, U1086 Anticipe Axe Cancers et Préventions, Caen, France; Université de Caen Normandie, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, Caen, France
- Lucile Migault
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
- Marine Renier
- INSERM, U1086 Anticipe Axe Cancers et Préventions, Caen, France; Université de Caen Normandie, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, Caen, France
- Virginie Rondeau
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
- Xavier Schwall
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
- Séverine Tual
- INSERM, U1086 Anticipe Axe Cancers et Préventions, Caen, France; Université de Caen Normandie, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, Caen, France
- Lebailly Pierre
- INSERM, U1086 Anticipe Axe Cancers et Préventions, Caen, France; Université de Caen Normandie, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, Caen, France
- Isabelle Baldi
- EPICENE team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France; Registre des tumeurs primitives du système nerveux central de la Gironde, ISPED, Centre INSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France; CHU de Bordeaux, Service de Médecine du Travail et Pathologies Professionnelles, Bordeaux, France; Corresponding author at: EPICENE team, ISPED, Unit U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, 146, rue Léo Saignat, 33076 Bordeaux, France.
- P. Arveux
- Registre des Cancers du Sein et Cancers Gynécologiques de Côte d'Or, France
- S. Bara
- Registre Général des Cancers de la Manche, France
- A.M. Bouvier
- Registre Bourguignon des Cancers Digestifs, France
- T. Busquet
- MSA Gironde, France
- M. Colonna
- Registre Général des Cancers de l'Isère, France
- G. Coureau
- Registre Général des Cancers de la Gironde, France
- M. Delanoé
- MSA Midi Pyrénées Nord, France
- P. Grosclaude
- Registre Général des Cancers du Tarn, France
- A.V. Guizard
- Registre Général des Tumeurs du Calvados, France
- P. Herbrecht
- MSA Alsace, France
- J.J. Laplante
- MSA Franche Comté, France
- B. Lapotre-Ledoux
- Registre Général des Cancers de la Somme, France
- G. Launoy
- Registre des Tumeurs Digestives du Calvados, France
- D. Lenoir
- MSA Bourgogne, France
- E. Marrer
- Registre Général des Cancers du Haut-Rhin, France
- E. Marcotullio
- Caisse Centrale de la MSA, France
- M. Maynadié
- Registre des Hémopathies Malignes Côte d'Or, France
- F. Molinié
- Registre Général de la Loire-Atlantique et Vendée, France
- A. Monnereau
- Registre des Hémopathies Malignes de la Gironde, France
- A. Paumier
- MSA Picardie, France
- P. Pouzet
- MSA Côtes Normandes, France
- J.M. Thibaudier
- MSA Alpes du Nord, France
- X. Troussard
- Registre Régional des Hémopathies Malignes de Basse Normandie, France
- M. Velten
- Registre Général des Cancers du Bas-Rhin, France
- E. Wavelet
- MSA Loire Atlantique-Vendée, France
- A.S. Woronoff
- Registre Général des Tumeurs du Doubs, France
- Journal volume & issue
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Vol. 130
Abstract
Background: Pesticides exposures could be implicated in the excess of Central Nervous System (CNS) tumors observed in farmers, but evidence concerning individual pesticides remains limited. Carbamate derivative pesticides, including herbicides and fungicides (i.e. (thio/dithio)-carbamates), have shown evidence of carcinogenicity in experimental studies in animals. In the French AGRICAN cohort, we assessed the associations between potential exposures to carbamate herbicides and fungicides and the incidence of CNS tumors, overall and by histological subtype. Methods: AGRICAN enrolled 181,842 participants involved in agriculture. Incident CNS tumors were identified by linkage with cancer registries from enrollment (2005–2007) until 2013. Individual exposures were assessed by combining information on lifetime periods of pesticide use on crops and the French crop-exposure matrix PESTIMAT, for each of the 14 carbamate and thiocarbamate herbicides and the 16 carbamate and dithiocarbamate fungicides registered in France since 1950. Associations were estimated using proportional hazard models with age as the underlying timescale, adjusting for gender, educational level and smoking. Results: During an average follow-up of 6.9 years, 381 incident cases of CNS tumors occurred, including 164 gliomas and 134 meningiomas. Analyses showed increased risks of CNS tumors with overall exposure to carbamate fungicides (Hazard Ratio, HR = 1.88; 95% CI: 1.27–2.79) and, to a lesser extent, to carbamate herbicides (HR = 1.44; 95% CI: 0.94–2.22). Positive associations were observed with specific carbamates, including some fungicides (mancozeb, maneb, metiram) and herbicides (chlorpropham, propham, diallate) already suspected of being carcinogens in humans. Conclusions: Although some associations need to be corroborate in further studies and should be interpreted cautiously, these findings provide additional carcinogenicity evidence for several carbamate fungicides and herbicides. Keywords: Carbamates, Thiocarbamates, Dithiocarbamates, Herbicides, Fungicides, CNS tumors, Occupational exposure, Risk factors, Cohort studies
