Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1

Karla E. Merz; Jinhee Hwang; Chunxue Zhou; Rajakrishnan Veluthakal; Erika M. McCown; Angelica Hamilton; Eunjin Oh; Wenting Dai; Patrick T. Fueger; Lei Jiang; Janice. M. Huss; Debbie C. Thurmond

doi:10.1038/s41467-022-28061-w

Nature Communications (Jan 2022)

Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1

Karla E. Merz,
Jinhee Hwang,
Chunxue Zhou,
Rajakrishnan Veluthakal,
Erika M. McCown,
Angelica Hamilton,
Eunjin Oh,
Wenting Dai,
Patrick T. Fueger,
Lei Jiang,
Janice. M. Huss,
Debbie C. Thurmond

Affiliations

Karla E. Merz: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Jinhee Hwang: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Chunxue Zhou: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Rajakrishnan Veluthakal: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Erika M. McCown: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Angelica Hamilton: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Eunjin Oh: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Wenting Dai: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Patrick T. Fueger: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Lei Jiang: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Janice. M. Huss: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope
Debbie C. Thurmond: Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope

DOI: https://doi.org/10.1038/s41467-022-28061-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

STX4 is a regulator of the glucose transporter GLUT4 vesicle fusion at the plasma membrane in skeletal muscle. Here, the authors show that skeletal muscle-specific STX4 enrichment reverses established insulin resistance and improves mitochondrial function in the context of diabetogenic stress.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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