Clinical Pharmacology: Advances and Applications (Oct 2021)
A Case of Thrombocytosis Associated with Enoxaparin Therapy in an Adolescent
Abstract
Robert Murray,1 Joseph T Tobias1– 3 1Department of Pediatrics, Division of Pediatric Critical Care Medicine, Nationwide Children’s Hospital, Columbus, OH, USA; 2Department of Anesthesiology & Pain Medicine, Nationwide Children’s Hospital, Columbus, OH, USA; 3Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, Columbus, OH, USACorrespondence: Robert MurrayDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH, 43205, USATel +1 614 722-4200Fax +1 614 722-4203Email [email protected]: Secondary thrombocytosis, often referred to as a reactive thrombocytosis, is more common than primary thrombocytosis and has many potential etiologies including anemia, infection, inflammation, medications, and post-splenectomy. When considering the critically ill patient in the ICU setting potential medication-related etiologies of thrombocytosis should be included in the differential diagnosis. We present a 15-year-old adolescent with a traumatic brain injury who developed thrombocytosis that was temporally related to the administration of enoxaparin. There was a prompt return of the platelet count to normal following the discontinuation of enoxaparin therapy which led to the probable diagnosis of enoxaparin-induced thrombocytosis.Keywords: enoxaparin, thrombocytosis, platelet count, heparin, anticoagulation
