Nature Communications (Jun 2021)

The nanoscale molecular morphology of docked exocytic dense-core vesicles in neuroendocrine cells

  • Bijeta Prasai,
  • Gideon J. Haber,
  • Marie-Paule Strub,
  • Regina Ahn,
  • John A. Ciemniecki,
  • Kem A. Sochacki,
  • Justin W. Taraska

DOI
https://doi.org/10.1038/s41467-021-24167-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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The molecular organization of exocytic vesicles regulates their transport and fusion. Prasai, Taraska, and colleagues use correlative light and electron microscopy, along with 3D tomography and gold labeling, to directly map proteins on single exocytic organelles at the plasma membrane.