Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes

Niina Sandholm; Jani K Haukka; Iiro Toppila; Erkka Valo; Valma Harjutsalo; Carol Forsblom; Per-Henrik Groop

doi:10.1038/s41598-018-29211-1

Scientific Reports (Aug 2018)

Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes

Niina Sandholm,
Jani K Haukka,
Iiro Toppila,
Erkka Valo,
Valma Harjutsalo,
Carol Forsblom,
Per-Henrik Groop

Affiliations

Niina Sandholm: Folkhälsan Institute of Genetics, Folkhälsan Research Center
Jani K Haukka: Folkhälsan Institute of Genetics, Folkhälsan Research Center
Iiro Toppila: Folkhälsan Institute of Genetics, Folkhälsan Research Center
Erkka Valo: Folkhälsan Institute of Genetics, Folkhälsan Research Center
Valma Harjutsalo: Folkhälsan Institute of Genetics, Folkhälsan Research Center
Carol Forsblom: Folkhälsan Institute of Genetics, Folkhälsan Research Center
Per-Henrik Groop: Folkhälsan Institute of Genetics, Folkhälsan Research Center

DOI: https://doi.org/10.1038/s41598-018-29211-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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Abstract Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third individual with diabetes. Despite substantial estimated heritability, only variants in the GLRA3 gene have been genome-wide significantly associated (p-value 7%; N = 2560, p = 1.7 × 10−9). Even though further studies are needed to pinpoint the causal variants, dissecting the association at the GLRA3 locus may uncover novel molecular mechanisms for diabetic albuminuria irrespective of population background.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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