CLINICAL AND RADIOLOGICAL CHARACTERISTICS OF ANCA-ASSOCIATED VASCULITIS: 7 YEARS OF EXPERIENCE IN DIAGNOSIS AND TREATMENT

Abstract

The aim of the research is to study nosological structure, features of kidney, lung damage, deaths in patients with ANCA – associated vasculitis underwent medical treatment in a multidisciplinary hospital. Material and methods. Selection and subsequent retrospective analysis of the medical histories of 38 inpatient patients observed in nephrological, rheumatological, pulmonological and surgical thoracic departments for the period from January 2012 to december 2018 were carried out. The disease main clinical symptoms, variants of the X-ray picture, and causes of death were assessed in the patients according to the clinical and laboratory examination. Results and discussion. The most common diagnosis was eosinophilic granulomatosis with polyangiitis (EGPA) – 16 cases; microscopic polyangiitis was diagnosed in 11 patients, granulomatosis with polyangiitis – in 9 persons. in 2 cases, ANCA-associated vasculitis was diagnosed without specifying the nosological form. The most common symptoms in patients with ANCA-vasculitis were fever, progressive shortness of breath, weakness, artalgia, eosinophilia, which occurred mainly in patients with EGPA. Among analyzed 38 cases, there were 6 men and 32 women. The average age of patients was 50.72 ± 12.6 years. There were 5 deaths and, in 2 cases, the outcome could not be clarified. All deaths occurred during the first year from the disease onset caused by infectious complications or severe manifestations of the main disease.

Keywords

• anca-associated vasculites
• microscopic polyangiitis
• granulomatosis with polyangiitis
• eosinophilic granulomatosis with polyangiitis
• interstitial lung lesions