iScience (Oct 2022)
Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern
- Peifang Sun,
- Irene Ramos,
- Camila H. Coelho,
- Alba Grifoni,
- Corey A. Balinsky,
- Sindhu Vangeti,
- Alison Tarke,
- Nathaniel I. Bloom,
- Vihasi Jani,
- Silvia J. Jakubski,
- David A. Boulifard,
- Elizabeth Cooper,
- Carl W. Goforth,
- Jan Marayag,
- Amethyst Marrone,
- Edgar Nunez,
- Lindsey White,
- Chad K. Porter,
- Victor A. Sugiharto,
- Megan Schilling,
- Avinash S. Mahajan,
- Charmagne Beckett,
- Alessandro Sette,
- Stuart C. Sealfon,
- Shane Crotty,
- Andrew G. Letizia
Affiliations
- Peifang Sun
- Naval Medical Research Center, Silver Spring, MD, USA
- Irene Ramos
- Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- Camila H. Coelho
- La Jolla Institute for Immunology, La Jolla, CA, USA
- Alba Grifoni
- La Jolla Institute for Immunology, La Jolla, CA, USA
- Corey A. Balinsky
- Naval Medical Research Center, Silver Spring, MD, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
- Sindhu Vangeti
- Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Stockholm University, Stockholm, Sweden
- Alison Tarke
- La Jolla Institute for Immunology, La Jolla, CA, USA
- Nathaniel I. Bloom
- La Jolla Institute for Immunology, La Jolla, CA, USA
- Vihasi Jani
- Naval Medical Research Center, Silver Spring, MD, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
- Silvia J. Jakubski
- Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
- David A. Boulifard
- Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
- Elizabeth Cooper
- Naval Medical Research Center, Silver Spring, MD, USA
- Carl W. Goforth
- Naval Medical Research Center, Silver Spring, MD, USA; Navy Medicine Readiness and Training Command, Jacksonville, FL, USA
- Jan Marayag
- Naval Medical Research Center, Silver Spring, MD, USA
- Amethyst Marrone
- Naval Medical Research Center, Silver Spring, MD, USA
- Edgar Nunez
- Naval Medical Research Center, Silver Spring, MD, USA
- Lindsey White
- Naval Medical Research Center, Silver Spring, MD, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
- Chad K. Porter
- Naval Medical Research Center, Silver Spring, MD, USA
- Victor A. Sugiharto
- Naval Medical Research Center, Silver Spring, MD, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
- Megan Schilling
- Naval Medical Research Center, Silver Spring, MD, USA
- Avinash S. Mahajan
- Icahn School of Medicine at Mount Sinai, New York, NY, USA
- Charmagne Beckett
- Naval Medical Research Center, Silver Spring, MD, USA
- Alessandro Sette
- La Jolla Institute for Immunology, La Jolla, CA, USA; Department of Medicine, University of California San Diego, San Diego, CA, USA
- Stuart C. Sealfon
- Icahn School of Medicine at Mount Sinai, New York, NY, USA; Corresponding author
- Shane Crotty
- La Jolla Institute for Immunology, La Jolla, CA, USA; Department of Medicine, University of California San Diego, San Diego, CA, USA; Corresponding author
- Andrew G. Letizia
- Naval Medical Research Center, Silver Spring, MD, USA; Naval Medical Research Unit-2-Asia, Singapore; Corresponding author
- Journal volume & issue
-
Vol. 25,
no. 10
p. 105202
Abstract
Summary: The ongoing evolution of SARS-CoV-2 requires monitoring the capability of immune responses to cross-recognize Variants of Concern (VOC). In this cross-sectional study, we examined serological and cell-mediated immune memory to SARS-CoV-2 variants, including Omicron, among a cohort of 18-21-year-old Marines with a history of either asymptomatic or mild SARS-CoV-2 infection 6 to 14 months earlier. Among the 210 participants in the study, 169 were unvaccinated while 41 received 2 doses of mRNA-based COVID-19 vaccines. Vaccination of previously infected participants strongly boosted neutralizing and binding activity and memory B and T cell responses including the recognition of Omicron, compared to infected but unvaccinated participants. Additionally, no measurable differences were observed in immune memory in healthy young adults with previous symptomatic or asymptomatic infections, for ancestral or variant strains. These results provide mechanistic immunological insights into population-based differences observed in immunity against Omicron and other variants among individuals with different clinical histories.
