Myelin oligodendrocyte glycoprotein antibody-associated encephalitis after severe acute respiratory syndrome coronavirus 2 infection: a case report and retrospective case reviews

Yoonkyung Lee; Seon-Jae Ahn; Han-Sang Lee; Yongmoo Kim; Seolah Lee; Hyeyoung Park; Jangsup Moon; Sang Kun Lee; Kon Chu

doi:10.47936/encephalitis.2022.00129

Encephalitis (Apr 2023)

Myelin oligodendrocyte glycoprotein antibody-associated encephalitis after severe acute respiratory syndrome coronavirus 2 infection: a case report and retrospective case reviews

Yoonkyung Lee,
Seon-Jae Ahn,
Han-Sang Lee,
Yongmoo Kim,
Seolah Lee,
Hyeyoung Park,
Jangsup Moon,
Sang Kun Lee,
Kon Chu

Affiliations

Yoonkyung Lee: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Seon-Jae Ahn: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Han-Sang Lee: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Yongmoo Kim: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Seolah Lee: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Hyeyoung Park: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Jangsup Moon: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Sang Kun Lee: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Kon Chu: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea

DOI: https://doi.org/10.47936/encephalitis.2022.00129
Journal volume & issue: Vol. 3, no. 2
pp. 71 – 77

Abstract

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Several cases of myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis have been reported after coronavirus disease 2019 (COVID-19). In this case, the patient presented with focal status epilepticus with impaired awareness, auditory hallucinations, and incoherent speech after COVID-19. Brain magnetic resonance imaging revealed no specific findings. Cerebrospinal fluid results showed pleocytosis and MOG antibody testing confirmed anti-MOG antibody with live cell-based fluorescence-activated cell sorting assay. The patient was diagnosed with MOG antibody-associated autoimmune encephalitis and treated with intravenous immunoglobulin, rituximab, and tocilizumab. This case occurred presumably due to auto-antibody production following COVID-19.

Published in Encephalitis

ISSN: 2765-4559 (Print); 2734-1461 (Online)
Publisher: Korean Encephalitis and Neuroinflammation Society
Country of publisher: Korea, Republic of
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.encephalitisjournal.org/

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Abstract

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