A sandwiched patch toward leakage-free and anti-postoperative tissue adhesion sealing of intestinal injuries

Wei Yang; Chengkai Xuan; Xuemin Liu; Qiang Zhang; Kai Wu; Liming Bian; Xuetao Shi

Bioactive Materials (Jun 2023)

A sandwiched patch toward leakage-free and anti-postoperative tissue adhesion sealing of intestinal injuries

Wei Yang,
Chengkai Xuan,
Xuemin Liu,
Qiang Zhang,
Kai Wu,
Liming Bian,
Xuetao Shi

Affiliations

Wei Yang: National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, China
Chengkai Xuan: National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, China; Guangzhou Soonheal Medical Technology. Co, Ltd, Guangzhou, 510230, China
Xuemin Liu: National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, China
Qiang Zhang: National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, China
Kai Wu: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, China
Liming Bian: National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006, China; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, China; Corresponding author. National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China.
Xuetao Shi: National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, China; Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006, China; Corresponding author. School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, China.

Journal volume & issue: Vol. 24
pp. 112 – 123

Abstract

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Ideal repair of intestinal injury requires a combination of leakage-free sealing and postoperative antiadhesion. However, neither conventional hand-sewn closures nor existing bioglues/patches can achieve such a combination. To this end, we develop a sandwiched patch composed of an inner adhesive and an outer antiadhesive layer that are topologically linked together through a reinforced interlayer. The inner adhesive layer tightly and instantly adheres to the wound sites via -NHS chemistry; the outer antiadhesive layer can inhibit cell and protein fouling based on the zwitterion structure; and the interlayer enhances the bulk resilience of the patch under excessive deformation. This complementary trilayer patch (TLP) possesses a unique combination of instant wet adhesion, high mechanical strength, and biological inertness. Both rat and pig models demonstrate that the sandwiched TLP can effectively seal intestinal injuries and inhibit undesired postoperative tissue adhesion. The study provides valuable insight into the design of multifunctional bioadhesives to enhance the treatment efficacy of intestinal injuries.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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