Zhejiang Daxue xuebao. Lixue ban (May 2005)

Synthesis and antitumor activity of diiodo-platinum (II) complexes with symmetry and asymmetry amines(对称胺和不对称胺的二碘合铂(II)混配配合物的合成及其抗肿瘤活性)

  • ZHANGJin-chao(张金超),
  • GONGYu-qiu(龚钰秋),
  • ZHENGXiao-ming(郑小明),
  • GUIJing-rong(崔景荣),
  • YANGMeng-su(杨梦苏)

DOI
Journal volume & issue
Vol. 32, no. 3
pp. 292 – 294

Abstract

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合成了6种对称胺的二碘合铂(II)配合物cis-[Pt(CH3NH2)2I2](1)，cis-[Pt(C2H5NH2)2I2](2)和cis-[Pt（—NH2）2I2](3)以及不对称胺的二碘合铂(II)配合物cis-[Pt (CH3NH2) (NH3)I2](4)，cis-[Pt (C2H5NH2) (NH3)I2](5)和(cis-[Pt(—NH2)(NH3)I2](6).用元素分析和红外光谱对其进行了表征.体外抗肿瘤活性表明，不对称胺的二碘合铂(II)配合物的抗肿瘤活性明显好于其相应的对称胺的二碘合铂(II)配合物，载体基团环己胺可能是非常重要的药效基团.

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