South African Journal of Radiology (Mar 2023)

Imaging in Van Wyk Grumbach syndrome: An uncommon presentation of hypothyroidism

  • Poonam Sherwani,
  • Khanak K. Nandolia,
  • Kirti Joshi,
  • Radhapyari Lourembam

DOI
https://doi.org/10.4102/sajr.v27i1.2572
Journal volume & issue
Vol. 27, no. 1
pp. e1 – e4

Abstract

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Isosexual precocious puberty with ovarian masses in long-standing juvenile hypothyroidism is well described in the literature as Van Wyk Grumbach syndrome (VWGS). The present case reports this rare entity in a 4-year-old girl who was referred for imaging to evaluate the cause of non-traumatic bleeding per vagina. Antecedent history, clinical features and thyroid function tests were consistent with long-standing juvenile hypothyroidism with documented clinical response to thyroxine replacement therapy. Contribution: Typical clinical and radiological features of the syndrome are reported, which helps in the early diagnosis and management, henceforth avoiding the associated complications.

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