Emerging Roles of Primary Cilia in Glioma

Matthew R. Sarkisian; Matthew R. Sarkisian; Susan L. Semple-Rowland

doi:10.3389/fncel.2019.00055

Frontiers in Cellular Neuroscience (Feb 2019)

Emerging Roles of Primary Cilia in Glioma

Matthew R. Sarkisian,
Matthew R. Sarkisian,
Susan L. Semple-Rowland

Affiliations

Matthew R. Sarkisian: Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, United States
Matthew R. Sarkisian: Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, United States
Susan L. Semple-Rowland: Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, United States

DOI: https://doi.org/10.3389/fncel.2019.00055
Journal volume & issue: Vol. 13

Abstract

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Primary cilia are microtubule-based organelles that are typically present on cells during the G0 or G1-S/G2 phases of the cell cycle. Recent studies of glioblastoma (GBM) biopsies, a brain tumor that is notorious for its aggressive growth and resistance to treatment, show that many cells in the tumor lack cilia. At this point, it remains unclear whether primary cilia promote or suppress glioma tumorigenesis. In this review, we will discuss the different roles that have been proposed for primary cilia in glioma and how cilia may contribute to the resistance of these tumors to current therapies.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

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Abstract

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