Nature Communications (Nov 2016)

PEP-19 modulates calcium binding to calmodulin by electrostatic steering

  • Xu Wang,
  • John A. Putkey

DOI
https://doi.org/10.1038/ncomms13583
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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The protein PEP-19 increases the rates of calcium binding to calmodulin. Here, the authors report the structure of PEP-19 bound to the C-terminal domain of calmodulin, and are able to propose a mechanism for the observed increased calcium association rate.