Effect of HCV on lipids profile of HIV patients

Abstract

Abstract Background: There is a high prevalence of HCV-HIV co-infection. In this group of patients increase of insulin resistance and lipodystrophy has been discovered but still sufficient data about the lipid profile has not been performed. In this research we tried compare the lipid profile changes between HIV-HCV patients with HIV and HCV mono infected patients that came to Imam Khomeini consult center of behavioral diseases clinic and also the hepatitis clinic during 2008-2010. Methodes: This study was an analytical, cross sectional one and was done through comparison of three groups :HIV, HCV, and HIV/HCV. Each group contained of 30 patients. Results: Demographic variables such as age, behavioral attitudes, family history of cardiovascular diseases and hyperlipidemia did not have any difference between the 3 groups. The researcher also compared the parameters of liver disease including AST, ALT, and platelet between the aforementioned groups and found no significant difference among them.Moreover, when TG, Cholesterol, LDL, and HDL was compared between the groups it was found that the mean total of cholesterol and LDL decreased in the HIV/HCV group (p=.001).In addition, the 3 groups were also compared by the dyslipidemia criteria. (TG ≥ 200 mg/dl, cholesterol ≥ 240, HDL <40). When the 3 groups were compared by the dyslipidemia criteria it resulted in no significant difference between the 3 groups. Conclusions: Although HIV-HCV coinfected patients had lower mean cholesterol and LDL in comparison to the other two groups nevertheless no significant difference was found from the critical level of lipid profile between the 3 groups. Furthermore it was found that HCV can cause a decrease in cholesterol and LDL when it is accompanied by HIV. Keywords:HIV,HCV,dyslipidemia

Keywords

• HIV
• HCV
• dyslipidemia