Nature Communications (Mar 2017)
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses
- Yinjing Song,
- Lihua Lai,
- Zhenlu Chong,
- Jia He,
- Yuanyuan Zhang,
- Yue Xue,
- Yiwei Xie,
- Songchang Chen,
- Ping Dong,
- Luoquan Chen,
- Zhimin Chen,
- Feng Dai,
- Xiaopeng Wan,
- Peng Xiao,
- Xuetao Cao,
- Yang Liu,
- Qingqing Wang
Affiliations
- Yinjing Song
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Lihua Lai
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Zhenlu Chong
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Jia He
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Yuanyuan Zhang
- The Children’s Hospital, Zhejiang University School of Medicine
- Yue Xue
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Yiwei Xie
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Songchang Chen
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Ping Dong
- Department of Neurobiology, Zhejiang University School of Medicine
- Luoquan Chen
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Zhimin Chen
- The Children’s Hospital, Zhejiang University School of Medicine
- Feng Dai
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Xiaopeng Wan
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Peng Xiao
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Xuetao Cao
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Yang Liu
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- Qingqing Wang
- Institute of Immunology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
- DOI
- https://doi.org/10.1038/ncomms14654
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
The innate immune response to many RNA viruses depends on recognition of viral RNA by RIG-I. Here the authors show that, upon virus infection, FBXW7 interacts with RIG-I and inhibits ubiquitin-mediated degradation of RIG-I, resulting in increased interferon signallingin vitro and in vivo.
