Nature Communications (May 2021)

Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development

  • Jasmin Morandell,
  • Lena A. Schwarz,
  • Bernadette Basilico,
  • Saren Tasciyan,
  • Georgi Dimchev,
  • Armel Nicolas,
  • Christoph Sommer,
  • Caroline Kreuzinger,
  • Christoph P. Dotter,
  • Lisa S. Knaus,
  • Zoe Dobler,
  • Emanuele Cacci,
  • Florian K. M. Schur,
  • Johann G. Danzl,
  • Gaia Novarino

DOI
https://doi.org/10.1038/s41467-021-23123-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 22

Abstract

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De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 (CUL3) lead to autism spectrum disorder (ASD). Here, the authors show that Cul3 is essential to regulate neuronal migration by tightly regulating Plastin3 (Pls3). Pls3 cell-autonomously regulates cell migration by regulating the actin cytoskeleton organization.