Guoji laonian yixue zazhi (Jan 2024)
Expression of Serum Omentin-1 and Oxidative Stress Parameters in Elderly Patients withType 2 Diabetes Mellitus Complicated with Osteoporosis
Abstract
Objective To investigate the expression of serum omentin-1 and oxidative stress parameters in elderly patients with type 2 diabetes mellitus(T2DM) complicated with osteoporosis. Methods A prospective study was conducted in 148 elderly patients with T2DM admitted to Handan Central Hospital from January 2020 to January 2023.According to the T value of bone mineral density,the patients were divided into a normal bone mass group(51 cases),a osteopenia group (45 cases) and an osteoporosis group(52 cases).The expression of oxidative stress parameters such as serum Omentin-1,total superoxide dismutase(T-SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px),nuclear factor-E2 related factor 2(Nrf2) and heme oxygenase-1(HO-1) was detected. Results The serum levels of Omentin-1,T-SOD,GSH-Px and Nrf2 in the osteoporosis group and the osteopenia group were lower than those in the normal bone mass group(P<0.05),and the serum levels of Omentin-1,T-SOD,GSH-Px and Nrf2 in the osteoporosis group were lower than those in the osteopenia group(P<0.05).The levels of MDA and HO-1 in the osteoporosis group and osteopenia group were higher than those in the normal bone mass group(P<0.05),and the levels of MDA and HO-1 in osteoporosis group were higher than those in the osteopenia group(P<0.05). Conclusion Serum Omentin-1,T-SOD,GSH-Px,MDA,Nrf2 and HO-1 were abnormally expressed in elderly patients with T2DM complicated with osteoporosis,and these indicators can be used as a reference for oxidative stress response assessment and treatment in elderly patients with T2DM complicated with osteoporosis.
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