Acute toxicity of nickel nanoparticles in rats after intravenous injection

Abstract

Ruth R Magaye,1,* Xia Yue,1,* Baobo Zou,1 Hongbo Shi,1 Hongsheng Yu,2 Kui Liu,1 Xialu Lin,1 Jin Xu,1 Cui Yang,3 Aiguo Wu,3 Jinshun Zhao1 1Public Health Department, 2Affiliated Hospital of Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, 3Key Laboratory of Magnetic Materials and Devices, Division of Functional Materials and Nano-devices, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo, People's Republic of China *These authors contributed equally to this work Abstract: This study was carried out to add scientific data in regard to the use of metallic nanoparticles in nanomedicine. The acute toxicity of nickel (Ni) nanoparticles (50 nm), intravenously injected through the dorsal penile vein of Sprague Dawley rats was evaluated in this study. Fourteen days after injection, Ni nanoparticles induced liver and spleen injury, lung inflammation, and caused cardiac toxicity. These results indicate that precautionary measures should be taken with regard to the use of Ni nanoparticles or Ni compounds in nanomedicine. Keywords: nickel, nanoparticles, intravenous, acute toxicity