Pulmonary Nodule Screening and Qualitative Diagnosis Based on Deep Learning

ZHANG Zhenghua; CAI Yaqian; HAN Dan; ZHOU Xiaojun; HUANG Yilong; LI Junli

doi:10.3971/j.issn.1000-8578.2020.19.1107

Zhongliu Fangzhi Yanjiu (Apr 2020)

Pulmonary Nodule Screening and Qualitative Diagnosis Based on Deep Learning

ZHANG Zhenghua,
CAI Yaqian,
HAN Dan,
ZHOU Xiaojun,
HUANG Yilong,
LI Junli

Affiliations

ZHANG Zhenghua: Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
CAI Yaqian: Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
HAN Dan: Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
ZHOU Xiaojun: Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
HUANG Yilong: Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
LI Junli: Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

DOI: https://doi.org/10.3971/j.issn.1000-8578.2020.19.1107
Journal volume & issue: Vol. 47, no. 4
pp. 283 – 287

Abstract

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Objective To explore the clinical application value of deep learning-based artificial intelligence (AI) in the detection and related quantitative measurement of pulmonary nodules. Methods We collected 250 cases of chest CT scan and compared the misdiagnosis rate, missed diagnosis rate, sensitivity, positive predictive value and average diagnosis time of pulmonary nodules among group A (hospitalized), group B (AI) and group C (hospitalized+AI). Meanwhile, AI quantization parameters of solid nodules and ground glass nodules (GGN) were compared, and ROC curve analysis was performed for the parameters with statistical difference. Results A total of 2230 nodules were identified. The misdiagnosis rate of group B was significantly higher than those of group A and C, and the positive predictive value was significantly lower than those of group A and C (P < 0.05). The rate of missed diagnosis in group A was significantly higher than those in group B and C, and the sensitivity was significantly lower than those in group B and C (P < 0.05). There were statistically significant differences in the long diameter, maximum area, volume, minimum CT value and malignant probability between solid benign and malignant nodules (P < 0.05). The indexes of area under the ROC curve (AUC) greater than 0.7 were: long diameter, maximum area, volume and malignant probability. There were statistically significant differences in the length, maximum area, volume, average CT value, maximum CT value and malignant probability between GGN benign and malignant nodules (P < 0.05). ROC curve analysis of all parameters showed that AUC was greater than 0.7. Conclusion AI-assisted film reading could significantly improve work efficiency and sensitivity of pulmonary nodules detection and reduce the rates of misdiagnosis and missed diagnosis. Meanwhile, it has certain reference value for the prediction of benign and malignant pulmonary nodules.

Published in Zhongliu Fangzhi Yanjiu

ISSN: 1000-8578 (Print)
Publisher: Magazine House of Cancer Research on Prevention and Treatment
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.zlfzyj.com

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