Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy

Lukas R. H. Gerken; Alexander Gogos; Fabian H. L. Starsich; Helena David; Maren E. Gerdes; Hans Schiefer; Serena Psoroulas; David Meer; Ludwig Plasswilm; Damien C. Weber; Inge K. Herrmann

doi:10.1038/s41467-022-30982-5

Nature Communications (Jun 2022)

Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy

Lukas R. H. Gerken,
Alexander Gogos,
Fabian H. L. Starsich,
Helena David,
Maren E. Gerdes,
Hans Schiefer,
Serena Psoroulas,
David Meer,
Ludwig Plasswilm,
Damien C. Weber,
Inge K. Herrmann

Affiliations

Lukas R. H. Gerken: Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE), Department of Mechanical and Process Engineering (D-MAVT), ETH Zurich
Alexander Gogos: Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE), Department of Mechanical and Process Engineering (D-MAVT), ETH Zurich
Fabian H. L. Starsich: Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE), Department of Mechanical and Process Engineering (D-MAVT), ETH Zurich
Helena David: Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE), Department of Mechanical and Process Engineering (D-MAVT), ETH Zurich
Maren E. Gerdes: Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE), Department of Mechanical and Process Engineering (D-MAVT), ETH Zurich
Hans Schiefer: Department of Radiation Oncology, Cantonal Hospital St. Gallen (KSSG)
Serena Psoroulas: Center for Proton Therapy, Paul Scherrer Institute (PSI)
David Meer: Center for Proton Therapy, Paul Scherrer Institute (PSI)
Ludwig Plasswilm: Department of Radiation Oncology, Cantonal Hospital St. Gallen (KSSG)
Damien C. Weber: Center for Proton Therapy, Paul Scherrer Institute (PSI)
Inge K. Herrmann: Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE), Department of Mechanical and Process Engineering (D-MAVT), ETH Zurich

DOI: https://doi.org/10.1038/s41467-022-30982-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Nanoparticles have recently received attention in radiation therapy since they can act as radioenhancers. In this article, the authors report on the dose enhancement capabilities of a series of nanoparticles based on their metal core composition and beam characteristics, obtaining designing criteria for their optimal performance in specific radiotreatments.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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